ASTI
Site Map  JAPANESE
Microneedle
lnavi_bu_m
Home > Intradermal

Intradermal Injection needles by Asti for effective intradermal vaccination

With the advancement in technology, we can observe that many revolutionary medical instruments and technological products are being introduced into the medical field for effective and faster treatment of various diseases. Irrespective of the technological advancements, injections have been the most important part in the treatment methods and are a primary choice for physicians for treating multiple diseases. Many studies reveal efficiency of intradermal vaccines through the injection before relying upon complicated technological solutions.

Such small thing like injection makes the job of a physician easier. Even for performing any surgeries or operation procedure, the primary step is to inject anesthesia with the help of injections. Asti is known for developing such injection needles that help the physicians to inject vaccines or any type of medicine in smoother manner. Our company is known for owning technologies to produce intradermal needles and injections which is used to effectively vaccinate patients.

INTRADERMAL

What is Intradermal Injection procedure?

Vaccines are generally instructed into the body mainly through three different types of injections. It falls under the category of subcutaneous method, Intramuscular method, and intradermal methods.

• In the Subcutaneous method, Injections are administered into sub-Q layer which is underneath skin.
• Whereas, in the intramuscular method, injections are administrated to muscle parts.
• In Intradermal injection procedure, injections are delivered to the dermis, which is skin layer underneath the epidermis.

The dermis has a high concentration of immune cells and is highly vascularized. Many studies have shown that intradermal injection is more effective than subcutaneous methods as dermis is home for skin-specific immunocompetent cells which induces the immune system into the body. The main advantage of intradermal injection is that it decreases the amount of vaccine required. Also, as these injections procedures are executed through micro-needles, injections can be inserted in a right intradermal injection depth which make the doctors administer vaccine into a body in the more efficient way.

Methods of Intradermal Injection with Asti


Injection Needle

As discussed, intradermal injections can be used with regular doses or by using the micro-needles. Here are different types of intradermal injections:

• With normal sized needles: These days, intradermal injections can also be delivered by conventional intradermal injection needles, by a method known as the Mantoux technique. In this technique, injections are introduced into the skin at an angle of 5 to 15 degrees which makes it difficult for normal doctors. Experienced doctors are required for the execution of this technique.

• Using microneedles: As standard needles are difficult to inject into the dermis part of a skin, microinjection has been the solution to intradermal injection. As dermis is located underneath epidermis, it can be accessed easily with the help of shorter needle (micro-needle) by placing it in right angles or 90 –degree angles to the skin. Asti produces specially designed micro-needles that can be used for intradermal injections. The micro-needles enable shallow fluid delivery at less than 1mm depth and multiple point injection. As discussed the advantage of this system that, it required fewer vaccines and is easily used which makes it simple for untrained staff to use this injection.

Asti known for producing the best micro-needles for the intradermal injections can help the doctors to inject the vaccine into patients in the most effective way possible. Intradermal Injection needle size is a factor which we take into consideration. Making the experience less painful, micro-needles will also help patients to save cost as they require less vaccine compared to other injection methods. We are the experts who manufacture the best needle gauge sizes for injections at affordable prices. Intradermal Delivery of Vaccine is now made easier with the services which Asti looks to offer.

intradermal flu vaccine, intradermal injection needle size, intradermal injection procedure

Skin surface to lumen middle: 0.35mm

intradermal vaccine, intradermal injection sites, intradermal injection angle

Flow path of the microneedle

intradermal injection needle, intradermal injection needle gauge, intradermal immunization

REFERENCES

1. Mikszta, JA, Haider MI, Pettis RJ. 2006.. Microneedles for drug and vaccine delivery: when will the dream become a reality? p. 309-325. In J. Wille (ed.), Skin delivery systems. Transdermals, dermatologicals, and cosmetic actives. Blackwell Press, Ames, IA.

2. Hickling JK, Jones KR, Friede M, et al. Intradermal delivery of vaccines: potential benefits and current challenges.. Bulletin of the World Health Organization 2011;89:221-226.

3. Marshall S, Sahm LJ, Moore AC. The success of microneedle-mediated vaccine delivery into skin. Hum Vaccin Immunother 2016;12:2975-2983.

4. Zehrung D, Kristensen D. Intradermal delivery of vaccines. A review of the literature and the potential for development for use in low- and middle- income countries. Seattle:Program for Appropriate Technology in Health (PATH). August 27, 2009

5.Troy SB, Kouiavskaia D, Siik J, et al. Comparison of the immunogenicity of various booster doses of inactivated polio vaccine delivered intradermally versus intramuscularly to HIV-infected adults. J Infect Dis 2015;211:1969-76.

6. Anand A, Zaman K, Estívariz CF, et al. Early priming with inactivated poliovirus vaccine (IPV) and intradermal fractional dose IPV administered by a microneedle device: A randomized controlled trial. Vaccine 2015;33:6816-22.

7. Beals CR, Railkar RA, Schaeffer AK, et al. Immune response and reactogenicity of intradermal administration versus subcutaneous administration of varicella-zoster virus vaccine: an exploratory, randomised, partly blinded trial. Lancet Infect Dis. 2016;16:915-22.